Synthesis and Evaluation of Novel Nucleic Acid Derivatives as Bioactive Substances
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چکیده
منابع مشابه
[Synthesis and evaluation of novel nucleic acid derivatives as bioactive substances].
This review describes the synthesis and evaluation of novel nucleic acid derivatives performed by our research group to date. We developed a new method for the synthesis of 2-alkoxyadenosine analogs via nonaqueous diazotization-dediazoniation reactions. By applying these reactions, we effectively synthesized four types of carbocyclic oxetanocin analogs (2-alkoxy-C.OXT-A). The angiogenic activit...
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Different acid chlorides (2a-d) reacted with anthranilic acid to produce 2-substituted-3, 1-benzoxazin-4-one (3a-d) which was used as starting material to synthesize some condensed and non-condensed heterocyclic compounds by reaction with nitrogen nucleophiles e.g., hydrazine hydrate, and formamide. Some of the newly synthesized analogues were chosen to evaluate their cytotoxic activity against...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2014
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.14-00175